Antipurinergic therapy for autism—An in-depth review
نویسندگان
چکیده
منابع مشابه
Antipurinergic therapy for autism-An in-depth review.
Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the abnormal persistence of a normal, alternative functional state of mitochondria? A small clinical trial published in 2017 suggests this is possible. Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis, this study of 10 boys, ages 5-14years, showed that all...
متن کاملassessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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15 صفحه اولAntipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model
BACKGROUND Autism spectrum disorders (ASDs) are caused by both genetic and environmental factors. Mitochondria act to connect genes and environment by regulating gene-encoded metabolic networks according to changes in the chemistry of the cell and its environment. Mitochondrial ATP and other metabolites are mitokines-signaling molecules made in mitochondria-that undergo regulated release from c...
متن کاملAntipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
BACKGROUND This study was designed to test a new approach to drug treatment of autism spectrum disorders (ASDs) in the Fragile X (Fmr1) knockout mouse model. METHODS We used behavioral analysis, mass spectrometry, metabolomics, electron microscopy, and western analysis to test the hypothesis that the disturbances in social behavior, novelty preference, metabolism, and synapse structure are tr...
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ژورنال
عنوان ژورنال: Mitochondrion
سال: 2018
ISSN: 1567-7249
DOI: 10.1016/j.mito.2017.12.007